Aprotinin versus tranexamic acid in children undergoing cardiac surgery: an observational study
نویسندگان
چکیده
منابع مشابه
Aprotinin vs. tranexamic acid in isolated coronary artery bypass surgery: A multicentre observational study.
BACKGROUND Aprotinin appears to be more efficacious than lysine analogues to reduce bleeding and transfusion of blood products in high-transfusion-risk cardiac surgical patients. However, in isolated coronary artery bypass graft (CABG) surgery, the results from head-to-head trials remain less conclusive. OBJECTIVE Our objective was to compare the efficacies and safety of aprotinin and tranexa...
متن کامل1344159 - Pharmacokinetics of Tranexamic Acid in Patients Undergoing Cardiac Surgery
Introduction: Tranexamic acid (TXA) is routinely used during cardiac surgical procedures involving cardiopulmonary bypass (CPB) in order to reduce blood loss [1]. Although the optimum dose of TXA has been a subject of debate, a dosing regimen also sometimes referred to as the BART dose remains a popular choice for high-risk cardiac surgery [2]. The pharmacokinetics of TXA during the perioperati...
متن کاملHemostatic effects of aprotinin, tranexamic acid and epsilon-aminocaproic acid in primary cardiac surgery.
BACKGROUND The effects of epsilon-aminocaproic acid (EACA) and tranexamic acid (TA) on bleeding and allogeneic transfusions, and the cost of pharmacological and transfusional treatment were compared to aprotinin (AP). METHODS We randomized 210 patients subjected to elective cardiac surgery. Of these, 68 patients received EACA (a bolus of 5 g, an infusion of 2 g/h, and 2.5 g in the priming), 7...
متن کاملA practical tranexamic acid dosing scheme based on population pharmacokinetics in children undergoing cardiac surgery.
BACKGROUND Pediatric cardiac surgery patients are at high risk for bleeding, and the antifibrinolytic drug tranexamic acid (TA) is often used to reduce blood loss. However, dosing schemes remain empirical as a consequence of the absence of pharmacokinetic study in this population. The authors' objectives were thus to investigate the population pharmacokinetics of TA in pediatric cardiac surgery...
متن کاملTranexamic acid in paediatric cardiac surgery.
BACKGROUND & OBJECTIVES Antifibrinolytic agents are used commonly in adult cardiac surgery to reduce postoperative blood loss. Paucity of literature on the use of a newer antifibrinolytic agent tranexamic acid (TA) in children undergoing cardiac surgery promoted us to conduct this study in children with cyanotic heart disease. METHODS One hundred and twenty consecutive children with cyanotic ...
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ژورنال
عنوان ژورنال: European Journal of Cardio-Thoracic Surgery
سال: 2019
ISSN: 1010-7940,1873-734X
DOI: 10.1093/ejcts/ezz088